| ncRNA name | hsa-miR-454 |
| ncRNA Category | miRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | UM samples and their morphologically normal tissues; human UM cell lines OCM‐1A, MUM‐2C, C918 and MUM‐2B; human melanocyte cell line D78 |
| Methods | qRT-PCR, Oligonucleotide transfection, Western blot, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma. |
| PubMed ID | 26296312 |
| Year | 2015 |
| Title | MicroRNA-454 functions as an oncogene by regulating PTEN in uveal melanoma. |
| Drug-related ncRNA | NO |
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